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East Java’s sequencing reveals similarities to Chinese, European coronavirus strains

first_imgAirlangga University’s Institute of Tropical Diseases (ITD-UNAIR) in Surabaya has completed six whole genome sequencing analysis on genetic data of SARS-CoV-2, of which four were found to be similar to the Chinese strain and two similar to the European strain.ITD-UNAIR director Maria Ingelusida said data of two whole virus genome sequences had been sent to Global Initiative on Sharing All Influenza Data (GISAID), while the four others were in the finishing phase at the lab.”Four isolated sequences of the virus we’ve analyzed are closer to the Chinese clade and two are closer to the European clade,” Maria told The Jakarta Post on Wednesday. She said that so far, there were three clades of SARS-CoV-2, namely type A (found in bats), type B of the Chinese strain, and type C of the European strain.The complete six isolated SARS-CoV-2 sequences were among 20 samples taken from COVID-19 patients in Surabaya and several other cities in East Java, she said.Read also: From test kits to robots, Indonesia develops locally made devices to aid COVID-19 battleMaria said SARS-CoV-2 whole genome sequence data provided virologists and molecular biologists with valuable information on important changes to antigen as well as valuable information for vaccine development.”This data is very important because genes will code proteins that are produced by the virus. Information on the protein is needed in vaccine development, for instance,” she said.She said ITD-UNAIR would continue its whole genome sequencing project with more samples to be analyzed.Topics : She said the six whole virus genome sequences might reveal the origin of SARS-CoV-2 in East Java. Data of three whole genome sequences submitted earlier by the Eijkman Institute for Molecular Biology to GISAID were all similar to the Chinese clade, she added.Read also: Coronavirus strain in Indonesia different from those of other countries, govt says”So, ours provides new findings in terms of the virus origin, that the virus transmission source here is also from Europe, not only China,” she said, adding that the whole genome sequence data could also tell the virus transmission path.Maria said SARS-CoV-2 was an ribonucleic acid (RNA) virus that easily mutated. Therefore, she said, the SARS-CoV-2 whole genome sequences from Indonesia would certainly have some genetic peculiarities although they were closer to either the Chinese branch or the European branch.  last_img read more

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Italian roundup: Minibond, Pioneer, BNP Paribas, Prometeia, PensPlan, Fondo Pegaso, Groupama

first_imgItalian asset manager Pioneer Investments has launched a €200m, five-year mini-bond fund to invest in Italian small and medium enterprises (SME).The closed fund, named Pioneer Progetto Italia, will invest in credit securities issued by firms with revenues between €10m and €100m and a minimum rating of B-.In a statement, Pioneer said that the fund would focus on companies with a “stable competitive position, credible growth pans, positive economic and financial parameters and that seek to finance further expansion, including on international markets”.The fund will have an option to continue operating for two years after the end of the five-year term. The minimum deposit is €150,000 and proceeds will be distributed annually to subscribers. There are four financing rounds of five months each until the fund reaches maximum capacity. Eidos Partners is advising Pioneer with the selection of firms that will issue the mini-bonds.Cinzia Tagliabue, chief executive of Pioneer Investments, said: “We believe we can contribute to the development of a direct brokerage network between asset management and investment that supports the Italian system.”Earlier this month, BNP Paribas Investment Partners Sgr, the Italian asset management arm of French bank BNP Paribas, announced that it had completed the first closing of BNP Paribas Bond Italia Pmi, another closed mini-bond fund that will invest in Italian SMEs.In the first round of financing, the fund raised €56m and targets an overall target of €150m. The fund has a seven-year term and the minimum deposit is €1m. Marco Barbaro, CEO of BNP Paribas Investment Partners Sgr, told Italian media that the fund has identified seven potential issuers of credit. Advisory firm Prometeia will assist the subscribers of the fund with further due diligence on the recipients.Pioneer Investments, which is owned by Italian banking group Unicredit, says that the mini-bond market is growing, with 30 funds launched – including one by PensPlan Invest – on the Extramot Pro segment of Borsa Italiana, the Milan Stock Exchange, since the creation of mini-bond by Italian lawmakers at the end of 2011.The market is now worth €12m and consists of securities with a 7-year term and coupons between 3% and 10% (6.5% on average).Mini-bonds were created by the ‘Development Decree’ of 2012 introduced by Mario Monti’s government, as a measure to encourage lending to SMEs.The measure has been the object of a passionate debate within the Italian institutional investor community, with critics arguing that pension funds and other investors should not step in to finance small and medium enterprises to make up for the lacking appetite for credit by the banking sector.In other news, Groupama Asset Management has won one of three mandates advertised by Fondo Pegaso, the second-pillar fund for employees of Italian utility companies.Groupama was awarded a global balanced mandate to manage a portfolio of global fixed income and equities for the €670m fund.last_img read more

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Arnold Palmer Invitational picks, sleepers for daily fantasy golf contests and betting advice

first_imgMORE DFS: Lineup Builder | StrategyRory McIlroy (7/1), Rickie Fowler (10/1), and Justin Rose (11/1) are the favorites but are trailed closely by Brooks Koepka, Jason Day, and Bryson DeChambeau all at 18/1 or better. This is an event where we typically see the one of the world’s elite take home the title with some rare exceptions being Matt Every (2014 and ’15), and Martin Laird (’11). This is a week where going in on one of the top three players is tempting, with the favorite, McIlroy, being extremely interesting considering he’s the defending champion and riding four straight top-five finishes.You can also snag some nice value if you decide to fade the top end in the betting markets and look to spread your exposure over some of the 15/1 – 40/1 range. The same can be said for DFS formats, and a balanced lineup with two players in the $9,000-$10,000 range looks like an attractive strategy.Before we get into this week’s picks, we have to point out that plenty of strategy goes into cashing winning DFS lineups and winning betting tickets. By now you should know the best place to start is RotoQL’s DFS tools and the BetQL Mobile App. Our easy-to-use RotoQL PGA Lineup Optimizer gives you a big advantage when you’re putting together DFS lineups, and our BetQL Trending Picks and Public Betting tools provide a massive edge when you’re making bets, regardless of bankroll size.I’m always ready to help, too, so check me out on Twitter (@DFSBenj) for even more NFL, NBA, MLB and PGA daily fantasy content and gambling advice.Key StatsStrokes Gained: ApproachApproach > 200 yardsPar 5 ScoringTotal DrivingBirdie or Better Percentage %Bermuda PuttingArnold Palmer Invitational picks (Daily Fantasy Golf)DFS Core Plays to Consider:  Top Tier: Rory McIlroy, Jason Day, Bryson DeChambeauMid-Range: Tommy Fleetwood, Keegan Bradley (GPP), Ian Poulter, Si-Woo Kim (GPP), Rafa Cabrera-Bello (Cash)Value Plays: Matthew Fitzpatrick, Kevin Kisner, J.T. Poston, Talor Gooch, Sung KangArnold Palmer Invitational betting adviceOutright Bets to Consider*odds via DraftKings SportsbookBryson DeChambeau 18/1DeChambeau enters Bay Hill off his worst showing of the season at WGC-Mexico, but I like him to bounce back in a big way at a course that is a perfect fit for his game. DeChambeau ranks inside of the top five on the PGA Tour in Par 5 birdie-or-better percentage, and he made a Sunday run to grab a solo second here last season. Odds of 18/1 offer a nice value for a player who has four wins in the past six months.Marc Leishman 28/1 + T5Leishman is another player who is in a nice bounce-back spot following a rough showing at WGC-Mexico. Leishman won this event back in 2017 and followed that up with a T7 last season. He ranks 20th in Par 5 birdie-or-better percentage this season and is 35th in SG: total. Last week we got an absolute show at the Honda Classic and it was easily my favorite event of the season despite the fact we just missed out on hitting Brooks Koepka at 14/1. The Florida swing rolls up the road to Bay Hill for the Arnold Palmer Invitational with a field that is loaded with top-end talent even with Tiger Woods out of the field. That means plenty of options for your PGA DFS contests and betting action.Bay Hill is a long golf course at just over 7,400 yards for a Par 72. Despite the long length, many holes will require players to go less than driver off the tee, and there will be an higher than usual percentage of approach shots that will fall in the plus-200 yard range. Bay Hill features a great set of Par 5s that are also the course’s best scoring chances. Winners of this event in the past have historically dominated on the Par 5s and then scored around par on the courses difficult set of Par 3s. Adam Hadwin 90/1 + T10There are a few interesting long shots this week, and Hadwin is standing out at his 90/1 number. Hadwin has flashed some nice upside this season with three top-10 finishes in nine starts and has a nice track record both at Bay Hill and in the state of Florida. Hadwin isn’t the longest off of the tee, but he is accurate enough to keep himself in play. He nabbed a sixth-place finish in his last last start at this event in 2017.Dart Throws: Kevin Kisner 100/1 + T10, Bud Cauley 100/1 + T10, Charl Schwartzel 125/1 + T10last_img read more

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Kartje: In the wake of LeBron’s exit, Cleveland hopes to have found a new savior

first_imgStill, Darwish adds, with Mayfield under center, “I’m more optimistic than I’ve been in years.”On this Sunday, however, hope slams headlong into a roadblock. Against the Chargers, Mayfield struggles, and the Browns lose badly. Expectations are tempered, ever so slightly.Nevertheless, the Browns and Bakermania have the city buzzing, just as basketball season approaches. The Cavs will open their first season post-LeBron unlike any other in recent memory, away from the microscope they once operated under. No one here is clamoring for the Cavs, whether for reasons of subconscious self-preservation or otherwise.This is a Browns city now, fans will tell you, it always has been. And so, in the wake of LeBron’s exit and the uncertainty in his exit, the city will cling tightly to its quarterback and the new hope he brings, for however long it might last.“Once football season is over,” LaChance says, “I think people will start to realize LeBron is gone. But right now, we’ve got to ride this while we can.” How athletes protesting the national anthem has evolved over 17 years Cleveland has always been a football town. That’s the cliche, anyway. On the Muni Lot tailgate, just across the highway from the Browns’ lakeside stadium, it’s the first thing everyone will tell a reporter from Los Angeles who comes around asking about LeBron.For years, they’ve waited desperately for the Browns to show some flicker of hope, wearing their loyalty through hopeless heartache as a badge of honor. Of course, it was during that painfully long wait that Cleveland just so happened to land one of the greatest basketball players of all time.But here, in Northeast Ohio, the Browns are gospel, a fixture every Sunday, and football’s roots run deep within the region. So when Baker Mayfield took over in Week 3, dripping with moxie as he led the long-hapless Browns to their first victory in 635 days, his arrival galvanized the city, just when it needed it most.Amid these tailgates, drenched in brown and orange, Bakermania is in full swing. His No. 6 jersey, already a top-10 seller in the NFL, is everywhere. Screen-printed shirts bearing his likeness are peddled in large piles, with slogans like “Baker, Baker, touchdown maker” or “Real Deal Mayfield.”A bright orange sign hangs at the entrance to the lot. “QB Purgatory, R.I.P., 1999-2018,” it declares. John Terwoord, the Cleveland native who made the sign, is already selling “I survived QB Purgatory” shirts. Like everyone else here, he’s found hope again.Across Cleveland, you can feel it. Bartenders conferring about the Browns, Uber drivers raving about Mayfield. He’s only been the quarterback for three weeks, and yet, the rookie has already ascended to mythic status in this Midwestern city. Darwish, who for more than a decade has held his own tailgate here, admits he’s worried how quickly Cleveland has fallen for its new quarterback. The city has been hurt before. “They see an instant spark, and they go buy jerseys and they call him their savior,” he says.Related Articles Trail Blazers beat Grizzlies in play-in, earn first-round series with the Lakers Lakers practice early hoping to answer all questions Lakers, Clippers schedules set for first round of NBA playoffs center_img CLEVELAND — A cold rain is falling outside Quicken Loans Arena, dripping steadily off the plastic tarps and steel scaffolding that surround the home of the Cleveland Cavaliers. On this gray October Saturday, days before a new NBA season begins, the building where LeBron James became the greatest basketball player on Earth is a construction site, empty and eerily silent, save for the pitter-patter of drizzle on steel beams and concrete.On the same day that James signed a four-year deal with the Lakers, leaving Cleveland for the second time, Cuyahoga County made its first payment on the arena’s $140 million renovation. Construction has been underway since. Around the building, signs promise a “TRANSFORMATION”. But the arena won’t be finished until next fall. For now, as a new era of basketball here begins, Cleveland and its team are left mid-metamorphosis, unable to fully move forward, unable to put the past fully behind them.As such, the specter of LeBron still lingers here, even as his once-towering presence has been scrubbed from view. The iconic banner of LeBron that once hung on the corner of Huron and Ontario Streets has been removed, leaving only a few black marks on the red brick, the only subtle reminders of the now-bygone era.Lamp posts outside the arena which once bared his likeness now declare the Cavs’ new motto, “All for One, One for All”. There are no banners featuring Kevin Love or J.R. Smith or stud rookie Collin Sexton; even their jerseys in the team store are arranged somewhat democratically. Where James was once prominently featured as the city’s outsized superstar, his image plastered everywhere, his influence felt across this lakeside city, now no Cavs player is bigger than any other. Newsroom GuidelinesNews TipsContact UsReport an Error AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREUCLA alum Kenny Clark signs four-year contract extension with PackersThis is the awkward ground on which the Cavs will open this NBA season. As Los Angeles ushers in a new era with LeBron, Cleveland is still understandably sorting out the complicated feelings that come with his absence. The sentiment is much different now than in 2010, when James left for Miami and enraged fans burned jerseys en masse. No one here is cursing his name or dowsing Nike gear in lighter fluid. Their divorce has been mostly amicable, anger replaced by understanding.“He brought us a championship,” says Jason Darwish, 42. “I’m not mad at him. But he doesn’t look right in a Lakers uniform.”Former Cleveland Cavaliers star LeBron James sits on the bench in the final minutes of the second half of an NBA game against the Atlanta Hawks, Friday, April 7, 2017, in Cleveland. (AP Photo/Tony Dejak)“He was Northeast Ohio, man,” adds Sol LaChance, 36. “We all saw him play in high school. He’s from here.”The pain of his exit is still there, buried deep beneath the surface. Maybe it always will be. But James ended the championship curse after 52 years, and for that, he would always have their undying respect. Though, as the NBA season begins and the reality of life without him sinks in, it helps that a new star is emerging, one the city is already ready to anoint as its sports savior.*** Trail Blazers, Grizzlies advance to NBA play-in game; Suns, Spurs see playoff dreams dashed last_img read more

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